Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and literature review.

Journal Article (Journal Article;Review)

RATIONALE: Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignant nasopharyngeal tumor with features resembling papillary thyroid carcinoma including nuclear positive expression of thyroid transcription factor-1 (TTF-1). PATIENT CONCERNS: A 64-year-old male presented with nasal bleeding and a foreign body sensation of the nasopharynx. Laryngoscopy revealed a 2.0-cm broad-based mass with a smooth surface on the posterior wall of the nasopharynx. A biopsy was obtained. DIAGNOSES: Histopathologic examination demonstrated tumor cells arranged in both papillary and glandular architecture. The tumor cells express nuclear immunoreactivity for TTF-1. The diagnosis of TL-LGNPPA was made. INTERVENTIONS: After the patient was diagnosed with TL-LGNPPA, he underwent complete surgical resection. OUTCOMES: There was no recurrence or evidence of metastatic disease at the 12-month follow-up. LESSONS: TL-LGNPPA is easy to misdiagnose as metastatic papillary thyroid carcinoma or other relative primary adenocarcinomas. It is important to have a broad differential diagnosis and know the key features of each entity because the prognosis and clinical treatment of each may differ.

Full Text

Duke Authors

Cited Authors

  • Zhang, W-L; Ma, S; Havrilla, L; Cai, L; Yu, C-Q; Shen, S; Xu, H-T; Wang, L; Yu, J-H; Lin, X-Y; Wang, E; Yang, L-H

Published Date

  • November 2017

Published In

Volume / Issue

  • 96 / 47

Start / End Page

  • e8851 -

PubMed ID

  • 29381996

Pubmed Central ID

  • PMC5708995

Electronic International Standard Serial Number (EISSN)

  • 1536-5964

Digital Object Identifier (DOI)

  • 10.1097/MD.0000000000008851


  • eng

Conference Location

  • United States