Patchy ischemic retinal whitening in acute central retinal vein occlusion.


Journal Article

OBJECTIVE: To describe a new fundus abnormality in nonischemic central retinal vein occlusion and its pathophysiologic basis. DESIGN: Retrospective, observational case series. PARTICIPANTS: Eleven consecutive patients from a community-based retina referral practice who had central retinal vein occlusion (CRVO) and patchy ischemic retinal whitening (PIRW) and 225 consecutive patients from the same practice with CRVO and no PIRW. RESULTS: Patchy ischemic retinal whitening occurs in younger patients with nonischemic CRVO (P < 0.0003) and is associated with better visual outcomes than without PIRW (P = 0.0201). Patchy ischemic retinal whitening has a perivenular distribution in the macula, has no fluorescein angiographic correlate in milder cases, can occur before any retinal hemorrhages or macular edema, and resolves in 2 to 4 weeks. Cilioretinal arteriolar insufficiency is a common finding associated with PIRW (5/11 cases). The laboratory evaluation of patients with PIRW is generally normal. CONCLUSIONS: Patchy ischemic retinal whitening is a useful fundus sign of nonischemic CRVO that can precede other signs. Familiarity with this sign and its correlates will allow accurate diagnosis and counseling of affected patients.

Full Text

Duke Authors

Cited Authors

  • Browning, DJ

Published Date

  • November 2002

Published In

Volume / Issue

  • 109 / 11

Start / End Page

  • 2154 - 2159

PubMed ID

  • 12414432

Pubmed Central ID

  • 12414432

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/s0161-6420(02)01217-4


  • eng

Conference Location

  • United States