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Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.

Publication ,  Journal Article
Yang, C-FJ; McSherry, F; Mayne, NR; Wang, X; Berry, MF; Tong, B; Harpole, DH; D'Amico, TA; Christensen, JD; Ready, NE; Klapper, JA
Published in: Ann Thorac Surg
March 2018

BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer. METHODS: From 2013 to 2017, postoperative data from patients who underwent surgery after neoadjuvant chemotherapy plus ipilimumab in the TOP1201 trial, an open label phase II trial (NCT01820754), were prospectively collected. The surgical outcomes from TOP1201 were compared with outcomes in a historical cohort of patients receiving standard preoperative chemotherapy followed by surgery identified from our institution's prospectively collected thoracic surgery database. RESULTS: In the TOP1201 trial, 13 patients were treated with preoperative chemotherapy and ipilimumab followed by surgery. In the historical cohort, 42 patients received preoperative chemotherapy by a platinum doublet regimen preoperative chemotherapy by a platinum doublet regimen without ipilimumab followed by lobectomy or pneumonectomy. The 30-day mortality in both groups was 0%. The most frequently occurring perioperative complications in the TOP1201 group were prolonged air leak (n = 2, 15%) and urinary tract infection (n = 2, 15%). The most common perioperative complication in the preoperative chemotherapy alone group was atrial fibrillation (n = 6, 14%). One patient (8%) had atrial fibrillation in the TOP1201 group. There was no apparent increased occurrence of adverse surgical outcomes for patients in the TOP1201 group compared with patients receiving standard of care neoadjuvant chemotherapy alone before surgery for stage II-IIIA non-small cell lung cancer. CONCLUSIONS: This report is the first to demonstrate the safety and feasibility of surgical resection after treatment with ipilimumab and chemotherapy in stage II-IIIA non-small-cell lung cancer.

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Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

March 2018

Volume

105

Issue

3

Start / End Page

924 / 929

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Respiratory System
  • Pneumonectomy
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Ipilimumab
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Yang, C.-F., McSherry, F., Mayne, N. R., Wang, X., Berry, M. F., Tong, B., … Klapper, J. A. (2018). Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer. Ann Thorac Surg, 105(3), 924–929. https://doi.org/10.1016/j.athoracsur.2017.09.030
Yang, Chi-Fu Jeffrey, Frances McSherry, Nicholas R. Mayne, Xiaofei Wang, Mark F. Berry, Betty Tong, David H. Harpole, et al. “Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.Ann Thorac Surg 105, no. 3 (March 2018): 924–29. https://doi.org/10.1016/j.athoracsur.2017.09.030.
Yang C-FJ, McSherry F, Mayne NR, Wang X, Berry MF, Tong B, et al. Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer. Ann Thorac Surg. 2018 Mar;105(3):924–9.
Yang, Chi-Fu Jeffrey, et al. “Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.Ann Thorac Surg, vol. 105, no. 3, Mar. 2018, pp. 924–29. Pubmed, doi:10.1016/j.athoracsur.2017.09.030.
Yang C-FJ, McSherry F, Mayne NR, Wang X, Berry MF, Tong B, Harpole DH, D’Amico TA, Christensen JD, Ready NE, Klapper JA. Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer. Ann Thorac Surg. 2018 Mar;105(3):924–929.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

March 2018

Volume

105

Issue

3

Start / End Page

924 / 929

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Respiratory System
  • Pneumonectomy
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Ipilimumab
  • Humans