Rapid regression of large cardiac rhabdomyomas in neonates after sirolimus therapy.


Journal Article

Cardiac rhabdomyomas are the most common tumours in children and are typically seen in association with the tuberous sclerosis complex. Although benign and often associated with spontaneous regression, in rare circumstances surgical resection is indicated to relieve obstruction or other mass-related effects. Recent clinical trials have demonstrated the benefits of mammalian target of rapamycin inhibitors for the treatment of other tumour sub-types associated with tuberous sclerosis. Here we report rapid regression of several massive cardiac rhadomyomas in two neonates with the use of the mammalian target of rapamycin inhibitor sirolimus.

Full Text

Duke Authors

Cited Authors

  • Weiland, MD; Bonello, K; Hill, KD

Published Date

  • March 2018

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 485 - 489

PubMed ID

  • 29233209

Pubmed Central ID

  • 29233209

Electronic International Standard Serial Number (EISSN)

  • 1467-1107

Digital Object Identifier (DOI)

  • 10.1017/S104795111700244X


  • eng

Conference Location

  • England