The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome.

Published

Journal Article (Review)

Cells have evolved into complex sensory machines that communicate with their microenvironment via mechanochemical signaling. Extracellular mechanical cues trigger complex biochemical pathways in the cell, which regulate various cellular processes. Integrin-mediated focal adhesions (FAs) are large multiprotein complexes, also known as the integrin adhesome, that link the extracellular matrix (ECM) to the actin cytoskeleton, and are part of powerful intracellular machinery orchestrating mechanotransduction pathways. As forces are transmitted across FAs, individual proteins undergo structural and functional changes that involve a conversion of chemical to mechanical energy. The local composition of early adhesions likely defines the regional stress levels and determines the type of newly recruited proteins, which in turn modify the local stress distribution. Various approaches have been used for detecting and exploring molecular mechanisms through which FAs are spatiotemporally regulated, however, many aspects are yet to be understood. Current knowledge on the molecular mechanisms of mechanosensitivity in adhesion proteins is discussed herein along with important questions yet to be addressed, are discussed.

Full Text

Duke Authors

Cited Authors

  • Shams, H; Hoffman, BD; Mofrad, MRK

Published Date

  • February 2018

Published In

Volume / Issue

  • 140 / 2

PubMed ID

  • 29272321

Pubmed Central ID

  • 29272321

Electronic International Standard Serial Number (EISSN)

  • 1528-8951

International Standard Serial Number (ISSN)

  • 0148-0731

Digital Object Identifier (DOI)

  • 10.1115/1.4038812

Language

  • eng