A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

Published

Journal Article

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multi-epitope nanofibers in a modular fashion.

Full Text

Duke Authors

Cited Authors

  • Wu, Y; Norberg, PK; Reap, EA; Congdon, KL; Fries, CN; Kelly, SH; Sampson, JH; Conticello, VP; Collier, JH

Published Date

  • December 11, 2017

Published In

Volume / Issue

  • 3 / 12

Start / End Page

  • 3128 - 3132

PubMed ID

  • 30740520

Pubmed Central ID

  • 30740520

International Standard Serial Number (ISSN)

  • 2373-9878

Digital Object Identifier (DOI)

  • 10.1021/acsbiomaterials.7b00561

Language

  • eng

Conference Location

  • United States