Balancing the benefits and harms of thyroid cancer surveillance in survivors of Childhood, adolescent and young adult cancer: Recommendations from the international Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium.

Journal Article (Journal Article;Review)

Radiation exposure to the thyroid gland during treatment of childhood, adolescent and young adult cancer (CAYAC) may cause differentiated thyroid cancer (DTC). Surveillance recommendations for DTC vary considerably, causing uncertainty about optimum screening practices. The International Late Effects of Childhood Cancer Guideline Harmonization Group, in collaboration with the PanCareSurFup Consortium, developed consensus recommendations for thyroid cancer surveillance in CAYAC survivors. These recommendations were developed by an international multidisciplinary panel that included 33 experts in relevant medical specialties who used a consistent and transparent process. Recommendations were graded according to the strength of underlying evidence and potential benefit gained by early detection and appropriate management. Of the two available surveillance strategies, thyroid ultrasound and neck palpation, neither was shown to be superior. Consequently, a decision aid was formulated to guide the health care provider in counseling the survivor. The recommendations highlight the need for shared decision making regarding whether to undergo surveillance for DTC and in the choice of surveillance modality.

Full Text

Duke Authors

Cited Authors

  • Clement, SC; Kremer, LCM; Verburg, FA; Simmons, JH; Goldfarb, M; Peeters, RP; Alexander, EK; Bardi, E; Brignardello, E; Constine, LS; Dinauer, CA; Drozd, VM; Felicetti, F; Frey, E; Heinzel, A; van den Heuvel-Eibrink, MM; Huang, SA; Links, TP; Lorenz, K; Mulder, RL; Neggers, SJ; Nieveen van Dijkum, EJM; Oeffinger, KC; van Rijn, RR; Rivkees, SA; Ronckers, CM; Schneider, AB; Skinner, R; Wasserman, JD; Wynn, T; Hudson, MM; Nathan, PC; van Santen, HM

Published Date

  • February 2018

Published In

Volume / Issue

  • 63 /

Start / End Page

  • 28 - 39

PubMed ID

  • 29202445

Pubmed Central ID

  • 29202445

Electronic International Standard Serial Number (EISSN)

  • 1532-1967

Digital Object Identifier (DOI)

  • 10.1016/j.ctrv.2017.11.005


  • eng

Conference Location

  • Netherlands