Time to Drug-Resistant Tuberculosis Treatment in a Prospective South African Cohort.

Published online

Journal Article

This study examined time to treatment initiation by age among a prospective cohort with drug-resistant tuberculosis (DR-TB). Participants aged 13 years or older nested within a cluster-randomized trial in 2 South African provinces were evaluated. Outcomes were treatment initiation within 5 days of DR-TB diagnosis (National Tuberculosis Program guidelines) and days from diagnosis to treatment. A total of 521 participants met inclusion criteria. Eighty-two patients (16%) met national guidelines; median time to treatment was 11 days (range = 0-180). No patient (age, sex, prior TB history, HIV status) or health system characteristics (geographic urban/rural location, province) were associated with treatment initiation per guidelines except geographic location (t = 3.64, degrees of freedom = 1, P = .0003). One in 6 individuals with DR-TB received treatment per guidelines, and average time to treatment was 11 days. Strategies are needed to decrease treatment delays and meet the recommended guidelines for treatment for patients of all ages.

Full Text

Duke Authors

Cited Authors

  • van de Water, BJ; Prvu Bettger, J; Silva, S; Humphreys, J; Cunningham, CK; Farley, JE

Published Date

  • 2017

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 2333794X17744140 -

PubMed ID

  • 29226191

Pubmed Central ID

  • 29226191

Electronic International Standard Serial Number (EISSN)

  • 2333-794X

Digital Object Identifier (DOI)

  • 10.1177/2333794X17744140


  • eng

Conference Location

  • United States