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Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.

Publication ,  Journal Article
Hosono, Y; Niknafs, YS; Prensner, JR; Iyer, MK; Dhanasekaran, SM; Mehra, R; Pitchiaya, S; Tien, J; Escara-Wilke, J; Poliakov, A; Chu, S-C ...
Published in: Cell
December 2017

Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and cancer specificity. Here, we functionally characterize a novel ultraconserved lncRNA, THOR (ENSG00000226856), which exhibits expression exclusively in testis and a broad range of human cancers. THOR knockdown and overexpression in multiple cell lines and animal models alters cell or tumor growth supporting an oncogenic role. We discovered a conserved interaction of THOR with IGF2BP1 and show that THOR contributes to the mRNA stabilization activities of IGF2BP1. Notably, transgenic THOR knockout produced fertilization defects in zebrafish and also conferred a resistance to melanoma onset. Likewise, ectopic expression of human THOR in zebrafish accelerated the onset of melanoma. THOR represents a novel class of functionally important cancer/testis lncRNAs whose structure and function have undergone positive evolutionary selection.

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Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

December 2017

Volume

171

Issue

7

Start / End Page

1559 / 1572.e20

Related Subject Headings

  • Zebrafish
  • Testis
  • RNA-Binding Proteins
  • RNA, Long Noncoding
  • Mice
  • Melanoma
  • Male
  • Humans
  • Gene Knockout Techniques
  • Disease Models, Animal
 

Citation

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ICMJE
MLA
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Hosono, Y., Niknafs, Y. S., Prensner, J. R., Iyer, M. K., Dhanasekaran, S. M., Mehra, R., … Chinnaiyan, A. M. (2017). Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell, 171(7), 1559-1572.e20. https://doi.org/10.1016/j.cell.2017.11.040
Hosono, Yasuyuki, Yashar S. Niknafs, John R. Prensner, Matthew K. Iyer, Saravana M. Dhanasekaran, Rohit Mehra, Sethuramasundaram Pitchiaya, et al. “Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.Cell 171, no. 7 (December 2017): 1559-1572.e20. https://doi.org/10.1016/j.cell.2017.11.040.
Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, et al. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell. 2017 Dec;171(7):1559-1572.e20.
Hosono, Yasuyuki, et al. “Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA.Cell, vol. 171, no. 7, Dec. 2017, pp. 1559-1572.e20. Epmc, doi:10.1016/j.cell.2017.11.040.
Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu S-C, Saleh S, Sankar K, Su F, Guo S, Qiao Y, Freier SM, Bui H-H, Cao X, Malik R, Johnson TM, Beer DG, Feng FY, Zhou W, Chinnaiyan AM. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell. 2017 Dec;171(7):1559-1572.e20.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

December 2017

Volume

171

Issue

7

Start / End Page

1559 / 1572.e20

Related Subject Headings

  • Zebrafish
  • Testis
  • RNA-Binding Proteins
  • RNA, Long Noncoding
  • Mice
  • Melanoma
  • Male
  • Humans
  • Gene Knockout Techniques
  • Disease Models, Animal