A public health nurse talks about her career trajectory, her entry into nursing research, and her research career in transgender health. Transgender people encounter many health and social disparities, yet medical and nursing professionals are often ill-prepared to care for this population of individuals. The nursing profession is well known for its contributions to population health and for developing nursing-led interventions to improve the health outcomes of marginalized populations. Hines urges nursing to take a more active stance in transgender health and is leading this effort by example.