Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.

Journal Article (Journal Article)

PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012. Patients with a primary diagnosis of cryptococcal, Coccidioides, Histoplasma, or Candida meningitis were included in the analysis. Data concerning healthcare resource utilization, prevalence and length of stay were collected for up to 5 years following the original diagnosis. RESULTS: Cryptococcal meningitis was the most prevalent type of fungal meningitis (70.1 % of cases over the duration of the study), followed by coccidioidomycosis (16.4 %), histoplasmosis (6.0 %) and candidiasis (7.6 %). Cryptococcal meningitis and candidiasis patients accrued the largest average charges ($103 236 and $103 803, respectively) and spent the most time in the hospital on average (70.6 and 79 days). Coccidioidomycosis and histoplasmosis patients also accrued substantial charges and time in the hospital ($82 439, 48.1 days; $78 609, 49.8 days, respectively). CONCLUSION: Our study characterizes the largest longitudinal cohort of fungal meningitis in the United States. Importantly, the health economic impact and long-term morbidity from these infections are quantified and reviewed. The healthcare resource utilization of fungal meningitis patients in the United States is substantial.

Full Text

Duke Authors

Cited Authors

  • Charalambous, LT; Premji, A; Tybout, C; Hunt, A; Cutshaw, D; Elsamadicy, AA; Yang, S; Xie, J; Giamberardino, C; Pagadala, P; Perfect, JR; Lad, SP

Published Date

  • February 2018

Published In

Volume / Issue

  • 67 / 2

Start / End Page

  • 215 - 227

PubMed ID

  • 29244019

Pubmed Central ID

  • PMC6557145

Electronic International Standard Serial Number (EISSN)

  • 1473-5644

Digital Object Identifier (DOI)

  • 10.1099/jmm.0.000656


  • eng

Conference Location

  • England