A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.

Journal Article

In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.

Full Text

Duke Authors

Cited Authors

  • Howard, BA; James, OG; Perkins, JM; Pagnanelli, RA; Borges-Neto, S; Reiman, RE

Published Date

  • 2017

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 2050313X17745203 -

PubMed ID

  • 29242746

Pubmed Central ID

  • PMC5724631

International Standard Serial Number (ISSN)

  • 2050-313X

Digital Object Identifier (DOI)

  • 10.1177/2050313X17745203


  • eng

Conference Location

  • England