A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.
Journal Article
In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
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Duke Authors
Cited Authors
- Howard, BA; James, OG; Perkins, JM; Pagnanelli, RA; Borges-Neto, S; Reiman, RE
Published Date
- 2017
Published In
Volume / Issue
- 5 /
Start / End Page
- 2050313X17745203 -
PubMed ID
- 29242746
Pubmed Central ID
- PMC5724631
International Standard Serial Number (ISSN)
- 2050-313X
Digital Object Identifier (DOI)
- 10.1177/2050313X17745203
Language
- eng
Conference Location
- England