Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).

Published

Journal Article

Four series of disubstituted carbazole-1-carboxamides were designed and synthesised as inhibitors of Bruton's tyrosine kinase (BTK). 4,7- and 4,6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of BTK, while 3,7- and 3,6-disubstituted carbazole-1-carboxamides were potent and selective inhibitors of Janus kinase 2 (JAK2).

Full Text

Cited Authors

  • Liu, Q; Batt, DG; Lippy, JS; Surti, N; Tebben, AJ; Muckelbauer, JK; Chen, L; An, Y; Chang, C; Pokross, M; Yang, Z; Wang, H; Burke, JR; Carter, PH; Tino, JA

Published Date

  • October 2015

Published In

Volume / Issue

  • 25 / 19

Start / End Page

  • 4265 - 4269

PubMed ID

  • 26320619

Pubmed Central ID

  • 26320619

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2015.07.102

Language

  • eng