Targeting I kappa B kinase for the treatment of inflammatory and other disorders.


Journal Article (Review)

The nuclear transcription factor NF kappa B plays a critical role in the pathogenesis of a number of human disorders, particularly those with an inflammatory component. Due to the fact that I kappa B kinase (IKK)-catalyzed phosphorylation of I kappa B proteins is an essential step in the signal-induced activation of NF kappa B, targeting this kinase represents a fascinating opportunity to develop novel therapeutics. In this review, the current understanding of the role of IKK/NF kappa B in disease processes will be discussed, along with evidence demonstrating that IKK inhibitors will be efficacious in disorders ranging from rheumatoid arthritis to cancer and diabetes. Potential mechanism-based toxicities will also be discussed.

Full Text

Duke Authors

Cited Authors

  • Burke, JR

Published Date

  • September 2003

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 720 - 728

PubMed ID

  • 14579522

Pubmed Central ID

  • 14579522

International Standard Serial Number (ISSN)

  • 1367-6733


  • eng

Conference Location

  • England