Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Journal Article (Journal Article)
A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure-activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.
- Kempson, J; Guo, J; Das, J; Moquin, RV; Spergel, SH; Watterson, SH; Langevine, CM; Dyckman, AJ; Pattoli, M; Burke, JR; Yang, X; Gillooly, KM; McIntyre, KW; Chen, L; Dodd, JH; McKinnon, M; Barrish, JC; Pitts, WJ
- May 15, 2009
Volume / Issue
- 19 / 10
Start / End Page
- 2646 - 2649
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)