Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.

Journal Article (Journal Article)

A new series of tricyclic-based inhibitors of IKK have been derived from an earlier lead compound. The synthesis and structure-activity relationships (SAR) are described. Compound 4k inhibited TNF production in rats stimulated with LPS.

Full Text

Duke Authors

Cited Authors

  • Kempson, J; Guo, J; Das, J; Moquin, RV; Spergel, SH; Watterson, SH; Langevine, CM; Dyckman, AJ; Pattoli, M; Burke, JR; Yang, X; Gillooly, KM; McIntyre, KW; Chen, L; Dodd, JH; McKinnon, M; Barrish, JC; Pitts, WJ

Published Date

  • May 15, 2009

Published In

Volume / Issue

  • 19 / 10

Start / End Page

  • 2646 - 2649

PubMed ID

  • 19376699

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.03.159


  • eng

Conference Location

  • England