Targeting phospholipase A2 for the treatment of inflammatory skin diseases.


Journal Article (Review)

Due to the problems associated with current treatments for inflammatory disorders of the skin, the pharmaceutical industry has focused on novel ways to treat these disorders. Lipid-derived eicosanoids, which play an important role in the underlying inflammation in psoriasis and atopic dermatitis, can be derived from the phospholipase (PLA)-dependent production of arachidonate. In this review, the characteristics and promise of PLA, inhibitors, which have shown activity in preclinical models of skin inflammation are discussed along with the challenges the field faces in developing clinical candidates.

Full Text

Duke Authors

Cited Authors

  • Burke, JR

Published Date

  • November 2001

Published In

Volume / Issue

  • 2 / 11

Start / End Page

  • 1549 - 1552

PubMed ID

  • 11763156

Pubmed Central ID

  • 11763156

International Standard Serial Number (ISSN)

  • 1472-4472


  • eng

Conference Location

  • England