Dicarboxylic acid inhibitors of phospholipase A2


Journal Article

Ten diacids were synthesized via a simple regio- and stereoselective aldol reaction. All of these compounds were good to excellent inhibitors of 14 kDa human platelet PLA2, and many of these derivatives displayed activity in a phorbol-ester induced mouse ear edema assay. One of the new compounds reported here was selected for further development as a potential antipsoriasis agent.

Full Text

Duke Authors

Cited Authors

  • Springer, DM; Luh, BY; D'Andrea, SV; Bronson, JJ; Mansuri, MM; Burke, JR; Gregor, KR; Stanley, PL; Tramposch, KM

Published In

Volume / Issue

  • 7 / 7

Start / End Page

  • 793 - 798

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/S0960-894X(97)00110-8

Citation Source

  • Scopus