IkappaB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges.


Journal Article (Review)

The nuclear transcription factor NF-kappaB has a crucial role in the pathogenesis of several human disorders, particularly those with an inflammatory component. Because the multisubunit IkappaB kinase (IKK) is vital for translating pro-inflammatory stimuli into the activation of NF-kappaB, this kinase provides an opportunity to develop novel therapeutics. In this article, we review the investigations, both genetic and pharmacological, that demonstrate the use of IKK inhibition in autoimmune and inflammatory disorders. It is still unclear what toxicities will be associated with IKK inhibitors; a discussion of the potential for mechanism-based toxicities such as teratogenicity, lymphopoietic defects and susceptibility to infection is also presented.

Full Text

Cited Authors

  • Strnad, J; Burke, JR

Published Date

  • March 2007

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 142 - 148

PubMed ID

  • 17287032

Pubmed Central ID

  • 17287032

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2007.01.005


  • eng