Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.


Journal Article

The identification of a potent series of IKK-beta selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-alpha release mouse model are described.

Full Text

Cited Authors

  • Belema, M; Bunker, A; Nguyen, VN; Beaulieu, F; Ouellet, C; Qiu, Y; Zhang, Y; Martel, A; Burke, JR; McIntyre, KW; Pattoli, MA; Daloisio, C; Gillooly, KM; Clarke, WJ; Brassil, PJ; Zusi, FC; Vyas, DM

Published Date

  • August 2007

Published In

Volume / Issue

  • 17 / 15

Start / End Page

  • 4284 - 4289

PubMed ID

  • 17540562

Pubmed Central ID

  • 17540562

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.05.031


  • eng