Investigation of maternal environmental exposures in association with self-reported preterm birth.


Journal Article

Identification of maternal environmental factors influencing preterm birth risks is important to understand the reasons for the increase in prematurity since 1990. Here, we utilized a health survey, the US National Health and Nutrition Examination Survey (NHANES) to search for personal environmental factors associated with preterm birth. 201 urine and blood markers of environmental factors, such as allergens, pollutants, and nutrients were assayed in mothers (range of N: 49-724) who answered questions about any children born preterm (delivery <37 weeks). We screened each of the 201 factors for association with any child born preterm adjusting by age, race/ethnicity, education, and household income. We attempted to verify the top finding, urinary bisphenol A, in an independent study of pregnant women attending Lucile Packard Children's Hospital. We conclude that the association between maternal urinary levels of bisphenol A and preterm birth should be evaluated in a larger epidemiological investigation.

Full Text

Duke Authors

Cited Authors

  • Patel, CJ; Yang, T; Hu, Z; Wen, Q; Sung, J; El-Sayed, YY; Cohen, H; Gould, J; Stevenson, DK; Shaw, GM; Ling, XB; Butte, AJ; March of Dimes Prematurity Research Center at Stanford University School of Medicine,

Published Date

  • June 2014

Published In

Volume / Issue

  • 45 /

Start / End Page

  • 1 - 7

PubMed ID

  • 24373932

Pubmed Central ID

  • 24373932

Electronic International Standard Serial Number (EISSN)

  • 1873-1708

International Standard Serial Number (ISSN)

  • 0890-6238

Digital Object Identifier (DOI)

  • 10.1016/j.reprotox.2013.12.005


  • eng