Cloud-based solution to identify statistically significant MS peaks differentiating sample categories.

Published

Journal Article

BACKGROUND: Mass spectrometry (MS) has evolved to become the primary high throughput tool for proteomics based biomarker discovery. Until now, multiple challenges in protein MS data analysis remain: large-scale and complex data set management; MS peak identification, indexing; and high dimensional peak differential analysis with the concurrent statistical tests based false discovery rate (FDR). "Turnkey" solutions are needed for biomarker investigations to rapidly process MS data sets to identify statistically significant peaks for subsequent validation. FINDINGS: Here we present an efficient and effective solution, which provides experimental biologists easy access to "cloud" computing capabilities to analyze MS data. The web portal can be accessed at http://transmed.stanford.edu/ssa/. CONCLUSIONS: Presented web application supplies large scale MS data online uploading and analysis with a simple user interface. This bioinformatic tool will facilitate the discovery of the potential protein biomarkers using MS.

Full Text

Duke Authors

Cited Authors

  • Ji, J; Ling, J; Jiang, H; Wen, Q; Whitin, JC; Tian, L; Cohen, HJ; Ling, XB

Published Date

  • January 2013

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 109 -

PubMed ID

  • 23522030

Pubmed Central ID

  • 23522030

Electronic International Standard Serial Number (EISSN)

  • 1756-0500

International Standard Serial Number (ISSN)

  • 1756-0500

Digital Object Identifier (DOI)

  • 10.1186/1756-0500-6-109

Language

  • eng