Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.


Journal Article

The pharmacokinetics of continuous subcutaneous cytosine arabinoside (ara-C) infusions were compared with continuous intravenous infusions. Steady-state serum ara-C levels and myelosuppression were similar with both routes of administration. CSF/serum ara-C ratios ranged from 0.14 to 0.91 (mean, 0.58). Continuous subcutaneous ara-C infusions were a convenient and reliable alternative to intravenous infusions.

Full Text

Duke Authors

Cited Authors

  • Weinstein, HJ; Griffin, TW; Feeney, J; Cohen, HJ; Propper, RD; Sallan, SE

Published Date

  • June 1, 1982

Published In

Volume / Issue

  • 59 / 6

Start / End Page

  • 1351 - 1353

PubMed ID

  • 7082832

Pubmed Central ID

  • 7082832

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

International Standard Serial Number (ISSN)

  • 0006-4971


  • eng