Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity.


Journal Article

Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able to determine the relationship between enzymatic activity and protein content. In erythrocytes from a selenium-deficient individual who was treated with selenium, and in HL-60 cells grown in the absence of selenium and then returned to selenium-containing medium, there was a direct relationship between enzymatic activity and protein content. Thus, selenium deficiency results not only in a decrease of GSHPx activity, but also in a decrease of GSHPx protein.

Full Text

Duke Authors

Cited Authors

  • Takahashi, K; Newburger, PE; Cohen, HJ

Published Date

  • April 1986

Published In

Volume / Issue

  • 77 / 4

Start / End Page

  • 1402 - 1404

PubMed ID

  • 3457020

Pubmed Central ID

  • 3457020

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci112449


  • eng