Modulation of the respiratory burst in human neutrophils by isoproterenol and dibutyryl cyclic AMP.


Journal Article

The effects of a beta-adrenergic agonist and a cyclic AMP analogue on activation, activity, and termination of FMLP-stimulated superoxide anion production were investigated. Incubation with isoproterenol resulted in a 50% reduction in the maximal rate of superoxide production and a 3-4-fold increase in the rate of termination of superoxide production. Exposure to 1 mM dibutyryl cyclic AMP resulted in a 40% decrease in the maximal rate and a 3-fold increase in the rate of termination of FMLP-induced superoxide production. Neither agent had a significant effect on the lag time prior to superoxide anion generation.

Full Text

Duke Authors

Cited Authors

  • Gibson-Berry, KL; Whitin, JC; Cohen, HJ

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 43 / 1-2

Start / End Page

  • 59 - 68

PubMed ID

  • 8384637

Pubmed Central ID

  • 8384637

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(93)90075-a


  • eng