Reversal of biochemical and functional abnormalities in erythrocytes secondary to selenium deficiency.


Journal Article

A patient with multiple enterocutaneous fistulae on total parenteral nutrition for 14 months developed low erythrocyte selenium and low erythrocyte glutathione peroxidase. Erythrocyte hexose monophosphate shunt activity stimulated with an H2O2 generating system was approximately one-fourth that of control. Hexose monophosphate shunt activity stimulated with methylene blue showed little difference between patient and control. With selenium supplementation erythrocyte selenium, glutathione peroxidase, and hexose monophosphate shunt activity became normal. Thus, the biochemical and functional consequences of selenium deficiency can be corrected with selenium supplementation.

Full Text

Duke Authors

Cited Authors

  • Baker, SS; King, WW; Michel, L; Wood, WC; Malt, RA; Cohen, HJ

Published Date

  • May 1, 1983

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 293 - 295

PubMed ID

  • 6408277

Pubmed Central ID

  • 6408277

International Standard Serial Number (ISSN)

  • 0148-6071

Digital Object Identifier (DOI)

  • 10.1177/0148607183007003293


  • eng

Conference Location

  • United States