A Variant of Chronic Granulomatous Disease: Deficient Oxidative Metabolism Due to a Low-Affinity NADPH Oxidase


Journal Article

OUR defense against bacterial infections depends in part on the action of phagocytic leukocytes, which encounter and kill potentially pathogenic microorganisms. A severe reduction in the number or function of phagocytic leukocytes may predispose a person to peculiar, recurrent, or unusually severe infections. One of the first examples of such an impairment discovered was a genetic disorder called chronic granulomatous disease (CGD).1 Phagocytic leukocytes from patients with CGD have an impaired ability to kill certain microorganisms, because the phagocytes cannot produce metabolites of oxygen that are toxic to these microbes.2,3 It is believed that an appropriate perturbation of the phagocyte's. © 1981, Massachusetts Medical Society. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Lew, PD; Southwick, FS; Stossel, TP; Whitin, JC; Simons, E; Cohen, HJ

Published Date

  • November 26, 1981

Published In

Volume / Issue

  • 305 / 22

Start / End Page

  • 1329 - 1333

Electronic International Standard Serial Number (EISSN)

  • 1533-4406

International Standard Serial Number (ISSN)

  • 0028-4793

Digital Object Identifier (DOI)

  • 10.1056/NEJM198111263052207

Citation Source

  • Scopus