Cytogenetic findings in congenital leukemia: case report and review of the literature.
Journal Article
The cytogenetic findings in a five-week-old female infant with acute lymphoblastic leukemia (ALL) are reported. Markers 11q - and 19 + were observed and considered to be due to an interstitial deletion of segment 11q13 to 11q23 of chromosome #11 and an insertion of this segment into the terminal region of the short arm of #19. Previously published banded cases of leukemic infants under one year of age have been summarized. A review of the data in these 29 cases suggests that the appearance of a normal karyotype in acute leukemia of infants (less than or equal to 1 year old) is much less common than in other categories of acute leukemia. Fourteen out of 29 cases (48%) had chromosomal abnormalities involving 11q. Seven of eight ALL cases had aberrations with a breakpoint at 11q22-23; six cases had t(4;11), one case had a del(11q) and ins(19p), and another had a t(1;22;4). All of three AMMoL cases had translocations involving the long arm of #11. The percentage of patients with t(4;11) and certain translocations involving 11q in infants with ALL or AMMoL, respectively, is higher than that seen in ALL and AMMoL in general. Eleven out of 12 cases (92%) of infant acute leukemias with chromosomal abnormalities involving 11q22-23 were five months old or less.
Full Text
Duke Authors
Cited Authors
- Abe, R; Ryan, D; Cecalupo, A; Cohen, H; Sandberg, AA
Published Date
- June 1, 1983
Published In
Volume / Issue
- 9 / 2
Start / End Page
- 139 - 144
PubMed ID
- 6573948
Pubmed Central ID
- 6573948
International Standard Serial Number (ISSN)
- 0165-4608
Digital Object Identifier (DOI)
- 10.1016/0165-4608(83)90034-1
Language
- eng
Conference Location
- United States