More is better! Update of Dana-Farber Cancer Institute/Children's Hospital childhood acute lymphoblastic leukemia trials.


Journal Article (Review)

Between 1973 and 1985, 553 children with childhood acute lymphoblastic leukemia were treated on Dana-Farber Cancer Institute/Children's Hospital, Boston, protocols. The programs featured intensive remission induction therapy, CNS treatment with cranial irradiation and intrathecal drugs, doxorubicin intensification with or without asparaginase, and 2-21/2 years of conventional continuation therapy. There has been progressive improvement in event-free survival for each successive program. Leukemia control concerns pertain to: 1. late relapses (at greater than 5 years) in "standard-risk" patients; 2. an increased incidence of CNS relapses, especially in "standard-risk" patients, as preventative treatment is reduced in intensity; and 3. bone marrow relapses in "high-risk"patients. Comparisons of patients receiving the more intensive arm of each protocol with those receiving the less intensive arm support the hypothesis that more intensive chemotherapy results in improved event-free survival.

Full Text

Duke Authors

Cited Authors

  • Sallan, SE; Gelber, RD; Kimball, V; Donnelly, M; Cohen, HJ

Published Date

  • January 1990

Published In

Volume / Issue

  • 33 /

Start / End Page

  • 459 - 466

PubMed ID

  • 2182437

Pubmed Central ID

  • 2182437

International Standard Serial Number (ISSN)

  • 0171-7111

Digital Object Identifier (DOI)

  • 10.1007/978-3-642-74643-7_83


  • eng