Cytologic studies of glucose‐6‐phosphate dehydrogenase in malignancy


Journal Article

A histochemical technique for the determination of glucose‐6‐phosphate dehydrogenase (G6PD) was combined with cytologic studies of malignant tumor cells obtained by aspiration biopsy and touch preparations. Consistently high levels of G6PD activity were found in carcinoma cells of the colon. Lung cancer cells showed no or very weak enzyme activity in most cases. Wide variations in the level of this enzyme activity were noted in carcinoma of the breast and ovary while moderately strong activity occurred in cells from hypernephroma. Lympho‐proliferative diseases and soft tissue sarcomas also showed little or no activity. When combined with other cytohistologic enzyme determinations, patterns of enzyme activity corresponding to particular tissue origins became apparent. Copyright © 1968 American Cancer Society

Full Text

Duke Authors

Cited Authors

  • Cohen, HJ; Elizalde, A; Miller, SP

Published Date

  • January 1, 1968

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 1055 - 1060

Electronic International Standard Serial Number (EISSN)

  • 1097-0142

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(196806)21:6<1055::AID-CNCR2820210605>3.0.CO;2-1

Citation Source

  • Scopus