Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia.


Journal Article

Over the past several decades, L-asparaginase, an important component of therapy for acute lymphoblastic leukemia (ALL), has typically been administered intramuscularly rather than intravenously in North America because of concerns regarding anaphylaxis. We evaluated the feasibility of giving polyethylene glycosylated (PEG)-asparaginase, the polyethylene glycol conjugate of Escherichia coli L-asparaginase, by intravenous infusion in children with ALL. Between 2005 and 2007, 197 patients (age, 1-17 years) were enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 05-01 and received a single dose of intravenous PEG-asparaginase (2500 IU/m(2)) over 1 hour during remission induction. Serum asparaginase activity more than 0.1 IU/mL was detected in 95%, 88%, and 7% of patients at 11, 18, and 25 days after dosing, respectively. Toxicities included allergy (1.5%), venous thrombosis (2%), and pancreatitis (4.6%). We conclude that intravenous administration of PEG-asparaginase is tolerable in children with ALL, and potentially therapeutic enzyme activity is maintained for at least 2 weeks after a single dose in most patients. This trial was registered at as #NCT00400946.

Full Text

Duke Authors

Cited Authors

  • Silverman, LB; Supko, JG; Stevenson, KE; Woodward, C; Vrooman, LM; Neuberg, DS; Asselin, BL; Athale, UH; Clavell, L; Cole, PD; Kelly, KM; Laverdière, C; Michon, B; Schorin, M; Schwartz, CL; O'Brien, JE; Cohen, HJ; Sallan, SE

Published Date

  • February 2010

Published In

Volume / Issue

  • 115 / 7

Start / End Page

  • 1351 - 1353

PubMed ID

  • 20007809

Pubmed Central ID

  • 20007809

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2009-09-245951


  • eng