2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.

Journal Article (Journal Article)

We introduce a new strategy for synthesis of chiral amines: couplings of α-aminoalkyl nucleophiles generated by enantioselective migratory insertion of 2-azadienes to a Cu-H. In this report, we demonstrate its application in catalytic reductive coupling of 2-azadienes and ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.

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Duke Authors

Malcolmson, Steven

Cited Authors

Li, K; Shao, X; Tseng, L; Malcolmson, SJ

Published Date

January 2018

Published In

Journal of the American Chemical Society

Volume / Issue

140 / 2

Start / End Page

598 - 601

PubMed ID

29272124

Pubmed Central ID

PMC5936605

Electronic International Standard Serial Number (EISSN)

1520-5126

International Standard Serial Number (ISSN)

0002-7863

Digital Object Identifier (DOI)

10.1021/jacs.7b12213

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