2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.

Journal Article (Journal Article)

We introduce a new strategy for synthesis of chiral amines: couplings of α-aminoalkyl nucleophiles generated by enantioselective migratory insertion of 2-azadienes to a Cu-H. In this report, we demonstrate its application in catalytic reductive coupling of 2-azadienes and ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.

Full Text

Duke Authors

Cited Authors

  • Li, K; Shao, X; Tseng, L; Malcolmson, SJ

Published Date

  • January 2018

Published In

Volume / Issue

  • 140 / 2

Start / End Page

  • 598 - 601

PubMed ID

  • 29272124

Pubmed Central ID

  • PMC5936605

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/jacs.7b12213


  • eng