Effects of botulinum toxin A on upper limb spasticity in children with cerebral palsy.

Journal Article (Journal Article)

OBJECTIVE: Botulinum toxin A inhibits presynaptic release of acetylcholine at the neuromuscular junction and has reportedly been successful in the treatment of spastic disorders. This prospective study attempted to determine whether botulinum toxin A injection resulted in clinically measurable gains for 4 mo. DESIGN: Measurements were obtained from 32 children (range, 1-18 yr; average age, 6.9 yr) with hemiplegic or quadriplegic cerebral palsy before and at 1, 3, and 4 mo after botulinum toxin A injections. Spasticity was measured using the Modified Ashworth Scale for 12 different joints. RESULTS: Results showed that spasticity as measured by Ashworth scores for elbow and wrist extension clearly declined (P < 0.02) by 1 mo after botulinum toxin A injection, and diminished spasticity continued for 3-4 mo. Caregivers reported improvement in subjectively rated management, appearance, and function. However, patient response to botulinum toxin A injection was not predictable. Age had no significant relationship to gains. CONCLUSIONS: Further research is needed on the use of botulinum toxin A to diminish spasticity and improve function.

Full Text

Duke Authors

Cited Authors

  • Friedman, A; Diamond, M; Johnston, MV; Daffner, C

Published Date

  • 2000

Published In

Volume / Issue

  • 79 / 1

Start / End Page

  • 53 - 59

PubMed ID

  • 10678604

International Standard Serial Number (ISSN)

  • 0894-9115

Digital Object Identifier (DOI)

  • 10.1097/00002060-200001000-00012


  • eng

Conference Location

  • United States