Apoptosis in human retinal degenerations.


Conference Paper

PURPOSE: This paper examined the role of apoptosis in human retinal degenerations including pathologic myopia, age-related macular degeneration, serous retinal detachment, retinal lattice, and paving stone degenerations. METHOD: Thirty-seven enucleated human eyes with 1 of the above-mentioned retinal degenerations were studied by histopathology and by TdT-mediated biotin-dUTP nicked-end labelling (TUNEL) technique. RESULTS: Tunnel labelling characteristic DNA fragmentation of apoptosis was observed in photoreceptor cells in 2 of the 4 eyes with pathologic myopia and in 4 of 16 eyes with age-related macular degeneration, 2 of which were exudative and 2 of which were atrophic. However, only a few scattered photoreceptor cells were labelled in 4 of 8 eyes with serous retinal detachment secondary to malignant melanoma of the choroid. Moreover, none of the photoreceptors cells in the 4 eyes with retinal lattice degeneration and 6 eyes with retinal paving stone degeneration were labelled. CONCLUSIONS: Apoptosis is 1 of the important pathways of photoreceptor cell degeneration in pathologic myopia and age-related macular degeneration.

Full Text

Duke Authors

Cited Authors

  • Xu, GZ; Li, WW; Tso, MO

Published Date

  • 1996

Published In

Volume / Issue

  • 94 /

Start / End Page

  • 411 - 430

PubMed ID

  • 8981707

Pubmed Central ID

  • 8981707

International Standard Serial Number (ISSN)

  • 0065-9533

Conference Location

  • United States