Immunohistochemical and electron microscopic studies of Langerhans' cell histiocytosis (eosinophilic granuloma) of the orbit


Journal Article

Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surface glycoprotein T-6. We report here two cases of eosinophilic granuloma and review the immunologic role of Langerhans' cells with attention focused upon their unique morphologic traits.

Duke Authors

Cited Authors

  • Rodgers, IR; Font, RL; Friedman, AH; Guillory, SL; Jakobiec, FA; Boniuk, M

Published Date

  • December 1, 2006

Published In

Volume / Issue

  • 24 / 12

Start / End Page

  • 508 - 513

International Standard Serial Number (ISSN)

  • 1705-4842

Citation Source

  • Scopus