Overview of mouse models of autism spectrum disorders.

Published online

Journal Article (Review)

This overview describes many well characterized mouse models of autism spectrum disorders (ASDs). Mouse models considered here were selected because they are examples of genetically engineered models where human genetic evidence supports a causative relationship between the targeted mutation and the behavioral phenotype. As the ASD diagnosis is based primarily on behavioral evaluations in humans in the domains of social interaction, communication, and restricted interests, the murine phenotypes analogous to human autistic behaviors are highlighted for the different models and behaviors. Although genetically engineered mouse models with good construct and face validity are valuable for identifying and defining underlying pathophysiological mechanisms and for developing potential therapeutic interventions for the human condition, the translational value of various rodent behavioral assays remains a subject of debate. Significant challenges associated with modeling ASDs in rodents because of the clinical and molecular heterogeneity that characterize this disorder are also considered.

Full Text

Duke Authors

Cited Authors

  • Bey, AL; Jiang, Y-H

Published Date

  • September 2, 2014

Published In

Volume / Issue

  • 66 /

Start / End Page

  • 5.66.1 - 5.6626

PubMed ID

  • 25181011

Pubmed Central ID

  • 25181011

Electronic International Standard Serial Number (EISSN)

  • 1934-8290

Digital Object Identifier (DOI)

  • 10.1002/0471141755.ph0566s66

Language

  • eng

Conference Location

  • United States