Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.

Published online

Journal Article

The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regeneration and repair. Using the ablation of epidermal caspase-8 as a model of wound healing in Mus musculus, we analyzed the signaling components responsible for epithelial stem cell proliferation. We found that IL-1α and IL-7 secreted from keratinocytes work in tandem to expand the activated population of resident epidermal γδT-cells. A downstream effect of activated γδT-cells is the preferential proliferation of hair follicle stem cells. By contrast, IL-1α-dependent stimulation of dermal fibroblasts optimally stimulates epidermal stem cell proliferation. These findings provide new mechanistic insights into the regulation and function of epidermal cell-immune cell interactions and into how components that are classically associated with inflammation can differentially influence distinct stem cell niches within a tissue.

Full Text

Duke Authors

Cited Authors

  • Lee, P; Gund, R; Dutta, A; Pincha, N; Rana, I; Ghosh, S; Witherden, D; Kandyba, E; MacLeod, A; Kobielak, K; Havran, WL; Jamora, C

Published Date

  • December 4, 2017

Published In

Volume / Issue

  • 6 /

PubMed ID

  • 29199946

Pubmed Central ID

  • 29199946

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.28875

Language

  • eng

Conference Location

  • England