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Genetic studies of human neuropathic pain conditions: a review.

Publication ,  Journal Article
Zorina-Lichtenwalter, K; Parisien, M; Diatchenko, L
Published in: Pain
March 2018

Numerous studies have shown associations between genetic variants and neuropathic pain disorders. Rare monogenic disorders are caused by mutations of substantial effect size in a single gene, whereas common disorders are likely to have a contribution from multiple genetic variants of mild effect size, representing different biological pathways. In this review, we survey the reported genetic contributors to neuropathic pain and submit them for validation in a 150,000-participant sample of the U.K. Biobank cohort. Successfully replicated association with a neuropathic pain construct for 2 variants in IL10 underscores the importance of neuroimmune interactions, whereas genome-wide significant association with low back pain (P = 1.3e-8) and false discovery rate 5% significant associations with hip, knee, and neck pain for variant rs7734804 upstream of the MAT2B gene provide evidence of shared contributing mechanisms to overlapping pain conditions at the molecular genetic level.

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Published In

Pain

DOI

EISSN

1872-6623

Publication Date

March 2018

Volume

159

Issue

3

Start / End Page

583 / 594

Location

United States

Related Subject Headings

  • United Kingdom
  • Neuralgia
  • Methionine Adenosyltransferase
  • Interleukin-10
  • Humans
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Genetic Association Studies
  • Anesthesiology
  • 52 Psychology
 

Citation

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Zorina-Lichtenwalter, K., Parisien, M., & Diatchenko, L. (2018). Genetic studies of human neuropathic pain conditions: a review. Pain, 159(3), 583–594. https://doi.org/10.1097/j.pain.0000000000001099
Zorina-Lichtenwalter, Katerina, Marc Parisien, and Luda Diatchenko. “Genetic studies of human neuropathic pain conditions: a review.Pain 159, no. 3 (March 2018): 583–94. https://doi.org/10.1097/j.pain.0000000000001099.
Zorina-Lichtenwalter K, Parisien M, Diatchenko L. Genetic studies of human neuropathic pain conditions: a review. Pain. 2018 Mar;159(3):583–94.
Zorina-Lichtenwalter, Katerina, et al. “Genetic studies of human neuropathic pain conditions: a review.Pain, vol. 159, no. 3, Mar. 2018, pp. 583–94. Pubmed, doi:10.1097/j.pain.0000000000001099.
Zorina-Lichtenwalter K, Parisien M, Diatchenko L. Genetic studies of human neuropathic pain conditions: a review. Pain. 2018 Mar;159(3):583–594.

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

March 2018

Volume

159

Issue

3

Start / End Page

583 / 594

Location

United States

Related Subject Headings

  • United Kingdom
  • Neuralgia
  • Methionine Adenosyltransferase
  • Interleukin-10
  • Humans
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Genetic Association Studies
  • Anesthesiology
  • 52 Psychology