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Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia.

Publication ,  Journal Article
Koh, MT; Shao, Y; Sherwood, A; Smith, DR
Published in: Schizophr Res
March 2016

The hippocampus of patients with schizophrenia displays aberrant excess neuronal activity which affects cognitive function. Animal models of the illness have recapitulated the overactivity in the hippocampus, with a corresponding regionally localized reduction of inhibitory interneurons, consistent with that observed in patients. To better understand whether cognitive function is similarly affected in these models of hippocampal overactivity, we tested a ketamine mouse model of schizophrenia for cognitive performance in hippocampal- and medial prefrontal cortex (mPFC)-dependent tasks. We found that adult mice exposed to ketamine during adolescence were impaired on a trace fear conditioning protocol that relies on the integrity of the hippocampus. Conversely, the performance of the mice was normal on a delayed response task that is sensitive to mPFC damage. We confirmed that ketamine-exposed mice had reduced parvalbumin-positive interneurons in the hippocampus, specifically in the CA1, but not in the mPFC in keeping with the behavioral findings. These results strengthened the utility of the ketamine model for preclinical investigations of hippocampal overactivity in schizophrenia.

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Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

March 2016

Volume

171

Issue

1-3

Start / End Page

187 / 194

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Schizophrenia
  • Reaction Time
  • Psychiatry
  • Parvalbumins
  • Mice, Inbred C57BL
  • Mice
  • Memory Disorders
  • Male
  • Locomotion
 

Citation

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ICMJE
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Koh, M. T., Shao, Y., Sherwood, A., & Smith, D. R. (2016). Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia. Schizophr Res, 171(1–3), 187–194. https://doi.org/10.1016/j.schres.2016.01.023
Koh, Ming Teng, Yi Shao, Andrew Sherwood, and Dani R. Smith. “Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia.Schizophr Res 171, no. 1–3 (March 2016): 187–94. https://doi.org/10.1016/j.schres.2016.01.023.
Koh, Ming Teng, et al. “Impaired hippocampal-dependent memory and reduced parvalbumin-positive interneurons in a ketamine mouse model of schizophrenia.Schizophr Res, vol. 171, no. 1–3, Mar. 2016, pp. 187–94. Pubmed, doi:10.1016/j.schres.2016.01.023.
Journal cover image

Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

March 2016

Volume

171

Issue

1-3

Start / End Page

187 / 194

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Schizophrenia
  • Reaction Time
  • Psychiatry
  • Parvalbumins
  • Mice, Inbred C57BL
  • Mice
  • Memory Disorders
  • Male
  • Locomotion