Tissue-Resident Macrophages in Fungal Infections.

Journal Article (Journal Article;Review)

Invasive fungal infections result in high morbidity and mortality. Host organs targeted by fungal pathogens vary depending on the route of infection and fungal species encountered. Cryptococcus neoformans infects the respiratory tract and disseminates throughout the central nervous system. Candida albicans infects mucosal tissues and the skin, and systemic Candida infection in rodents has a tropism to the kidney. Aspergillus fumigatus reaches distal areas of the lung once inhaled by the host. Across different tissues in naïve hosts, tissue-resident macrophages (TRMs) are one of the most populous cells of the innate immune system. Although they function to maintain homeostasis in a tissue-specific manner during steady state, TRMs may function as the first line of defense against invading pathogens and may regulate host immune responses. Thus, in any organs, TRMs are uniquely positioned and specifically programmed to function. This article reviews the current understanding of the roles of TRMs during major fungal infections.

Full Text

Duke Authors

Cited Authors

  • Xu, S; Shinohara, ML

Published Date

  • 2017

Published In

Volume / Issue

  • 8 /

Start / End Page

  • 1798 -

PubMed ID

  • 29312319

Pubmed Central ID

  • PMC5732976

International Standard Serial Number (ISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2017.01798


  • eng

Conference Location

  • Switzerland