Scholars@Duke

Transport of fluid and macromolecules in tumors

Publication ,  Conference
Jain, RK; Baxter, LT; Boucher, Y; Leunig, M; Yuan, F
Published in: American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
December 1, 1992

We have characterized steps in drug delivery using two tumor models: (i) an `isolated' tumor which grows in the body with only one arterial input and one venous output, so that we can measure directly what is going into a tumor and what is leaving a tumor; and (ii) a `transparent' tumor grown in a glass window in the ear of a rabbit or the dorsal skin of an immunodeficient mouse, so that we can monitor continuously and noninvasively various physiological events in a tumor with a 1-μm resolution. Our research has characterized three physiological barriers an agent encounters during this journey in solid tumors in animals and humans: (i) heterogeneous blood supply, (ii) elevated interstitial pressure, and (iii) large transport distances in the interstitium. In this presentation we discuss our recent findings of the physiological barriers to delivery of genetically engineered molecules in tumors, as well as some strategies to overcome these barriers.

Duke Scholars

Fan Yuan
Author Fan Yuan Biomedical Engineering

Published In

American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD

ISSN

0272-5673

ISBN

0791811115

Publication Date

December 1, 1992

Volume

231

Start / End Page

103 / 104

Related Subject Headings

  • Mechanical Engineering & Transports
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jain, R. K., Baxter, L. T., Boucher, Y., Leunig, M., & Yuan, F. (1992). Transport of fluid and macromolecules in tumors. In American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD (Vol. 231, pp. 103–104).
Jain, R. K., L. T. Baxter, Y. Boucher, M. Leunig, and F. Yuan. “Transport of fluid and macromolecules in tumors.” In American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD, 231:103–4, 1992.
Jain RK, Baxter LT, Boucher Y, Leunig M, Yuan F. Transport of fluid and macromolecules in tumors. In: American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD. 1992. p. 103–4.
Jain, R. K., et al. “Transport of fluid and macromolecules in tumors.” American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD, vol. 231, 1992, pp. 103–04.
Jain RK, Baxter LT, Boucher Y, Leunig M, Yuan F. Transport of fluid and macromolecules in tumors. American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD. 1992. p. 103–104.

Published In

American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD

ISSN

0272-5673

ISBN

0791811115

Publication Date

December 1, 1992

Volume

231

Start / End Page

103 / 104

Related Subject Headings

  • Mechanical Engineering & Transports