Transport of fluid and macromolecules in tumors
We have characterized steps in drug delivery using two tumor models: (i) an `isolated' tumor which grows in the body with only one arterial input and one venous output, so that we can measure directly what is going into a tumor and what is leaving a tumor; and (ii) a `transparent' tumor grown in a glass window in the ear of a rabbit or the dorsal skin of an immunodeficient mouse, so that we can monitor continuously and noninvasively various physiological events in a tumor with a 1-μm resolution. Our research has characterized three physiological barriers an agent encounters during this journey in solid tumors in animals and humans: (i) heterogeneous blood supply, (ii) elevated interstitial pressure, and (iii) large transport distances in the interstitium. In this presentation we discuss our recent findings of the physiological barriers to delivery of genetically engineered molecules in tumors, as well as some strategies to overcome these barriers.
Jain, RK; Baxter, LT; Boucher, Y; Leunig, M; Yuan, F
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)
International Standard Book Number 10 (ISBN-10)