Beyond the labeled line: variation in visual reference frames from intraparietal cortex to frontal eye fields and the superior colliculus

Journal Article (Academic article)

We accurately perceive the visual scene despite moving our eyes ~3 times per second, an ability that requires incorporation of eye position and retinal information. In this study, we assessed how this neural computation unfolds across three interconnected structures: frontal eye fields (FEF), intraparietal cortex (LIP/MIP), and the superior colliculus (SC). Single unit activity was assessed in head-restrained monkeys performing visually-guided saccades from different initial fixations. As previously shown, the receptive fields of most LIP/MIP neurons shifted to novel positions on the retina for each eye position, and these locations were not clearly related to each other in either eye- or head-centered coordinates (defined as hybrid coordinates). In contrast, the receptive fields of most SC neurons were stable in eye-centered coordinates. In FEF, visual signals were intermediate between those patterns: around 60% were eye-centered, whereas the remainder showed changes in receptive field location, boundaries, or responsiveness that rendered the response patterns hybrid or occasionally head-centered. These results suggest that FEF may act as a transitional step in an evolution of coordinates between LIP/MIP and SC. The persistence across cortical areas of mixed representations that do not provide unequivocal location labels in a consistent reference frame has implications for how these representations must be read-out.

Full Text

Duke Authors

Cited Authors

  • Caruso, V; Pages, D; Sommer, MA; Groh, J

Published Date

  • December 20, 2017

Published In

Volume / Issue

  • In Press /

Published By

PubMed ID

  • 29357464

Pubmed Central ID

  • PMC5966730

International Standard Serial Number (ISSN)

  • 1522-1598

Digital Object Identifier (DOI)

  • 10.1152/jn.00584.2017