Skip to main content
Journal cover image

Donor hepatic function: a factor in postreperfusion syndrome.

Publication ,  Journal Article
Ricciardi, R; Foley, DP; Quarfordt, SH; Donohue, SE; Wheeler, SM; Callery, MP; Meyers, WC
Published in: J Gastrointest Surg
2002

Reperfusion of support livers after cold preservation produces hemodynamic instability (i.e., postreperfusion syndrome) in the recipient during both orthotopic liver transplantation and extracorporeal liver perfusion. We evaluated the effect of the normal porcine cold-preserved support liver on healthy recipient hemodynamics and in situ liver function during extracorporeal liver perfusion. Support livers were harvested from Yorkshire pigs and reperfused in an extracorporeal circuit with a healthy, anesthetized recipient pig. Correlation analyses were performed between support liver variables of function (oxygen consumption, bile flow, and biliary phospholipid and cholesterol output) and both recipient hemodynamic stability (heart rate, blood pressure, urine output, and vasopressor use) and hepatic function (bile flow and biliary phospholipid secretion). The data indicate that optimally functioning support livers are associated with improved recipient hemodynamic stability manifested by decreased recipient heart rate and vasopressor use and increased recipient urine output. Support livers exhibiting poor biliary secretory function (i.e., bile flow and phospholipid output) were associated with similarly diminished recipient liver biliary secretory function. These data indicate that the functional condition of the support liver after harvest and cold preservation may influence both recipient hemodynamic parameters and the endogenous function of the recipient liver.

Duke Scholars

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

2002

Volume

6

Issue

2

Start / End Page

248 / 254

Location

Netherlands

Related Subject Headings

  • Transplantation, Homologous
  • Tissue Donors
  • Syndrome
  • Swine
  • Surgery
  • Risk Factors
  • Reperfusion Injury
  • Probability
  • Male
  • Liver Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ricciardi, R., Foley, D. P., Quarfordt, S. H., Donohue, S. E., Wheeler, S. M., Callery, M. P., & Meyers, W. C. (2002). Donor hepatic function: a factor in postreperfusion syndrome. J Gastrointest Surg, 6(2), 248–254. https://doi.org/10.1016/s1091-255x(01)00065-8
Ricciardi, Rocco, David P. Foley, Steven H. Quarfordt, Susan E. Donohue, Suzanne M. Wheeler, Mark P. Callery, and William C. Meyers. “Donor hepatic function: a factor in postreperfusion syndrome.J Gastrointest Surg 6, no. 2 (2002): 248–54. https://doi.org/10.1016/s1091-255x(01)00065-8.
Ricciardi R, Foley DP, Quarfordt SH, Donohue SE, Wheeler SM, Callery MP, et al. Donor hepatic function: a factor in postreperfusion syndrome. J Gastrointest Surg. 2002;6(2):248–54.
Ricciardi, Rocco, et al. “Donor hepatic function: a factor in postreperfusion syndrome.J Gastrointest Surg, vol. 6, no. 2, 2002, pp. 248–54. Pubmed, doi:10.1016/s1091-255x(01)00065-8.
Ricciardi R, Foley DP, Quarfordt SH, Donohue SE, Wheeler SM, Callery MP, Meyers WC. Donor hepatic function: a factor in postreperfusion syndrome. J Gastrointest Surg. 2002;6(2):248–254.
Journal cover image

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

2002

Volume

6

Issue

2

Start / End Page

248 / 254

Location

Netherlands

Related Subject Headings

  • Transplantation, Homologous
  • Tissue Donors
  • Syndrome
  • Swine
  • Surgery
  • Risk Factors
  • Reperfusion Injury
  • Probability
  • Male
  • Liver Transplantation