Inhibition of bile flow by intravenous arginine hydrochloride.
Publication
, Journal Article
Rotolo, FS; Meyers, WC
Published in: Surgery
September 1985
One proposed mechanism for the cholestasis associated with total parenteral nutrition is infusion of amino acids. Arginine, 19 mumol/kg/min, was infused for a short time in healthy dogs with a biliary fistula to test the effect of endogenous hormone release on bile flow and composition. Both plasma glucagon and blood glucose levels increased. Despite the release of the choleretic hormone, glucagon, bile flow decreased 30%. The suppression of bile flow was attributed to a decrease in the bile acid-dependent fraction of bile flow. Bile acid, cholesterol, and phospholipid output were all depressed.
Duke Scholars
Published In
Surgery
ISSN
0039-6060
Publication Date
September 1985
Volume
98
Issue
3
Start / End Page
459 / 464
Location
United States
Related Subject Headings
- Surgery
- Phospholipids
- Infusions, Parenteral
- Glucagon
- Female
- Dogs
- Disease Models, Animal
- Chronic Disease
- Cholesterol
- Cholestasis
Citation
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ICMJE
MLA
NLM
Rotolo, F. S., & Meyers, W. C. (1985). Inhibition of bile flow by intravenous arginine hydrochloride. Surgery, 98(3), 459–464.
Rotolo, F. S., and W. C. Meyers. “Inhibition of bile flow by intravenous arginine hydrochloride.” Surgery 98, no. 3 (September 1985): 459–64.
Rotolo FS, Meyers WC. Inhibition of bile flow by intravenous arginine hydrochloride. Surgery. 1985 Sep;98(3):459–64.
Rotolo, F. S., and W. C. Meyers. “Inhibition of bile flow by intravenous arginine hydrochloride.” Surgery, vol. 98, no. 3, Sept. 1985, pp. 459–64.
Rotolo FS, Meyers WC. Inhibition of bile flow by intravenous arginine hydrochloride. Surgery. 1985 Sep;98(3):459–464.
Published In
Surgery
ISSN
0039-6060
Publication Date
September 1985
Volume
98
Issue
3
Start / End Page
459 / 464
Location
United States
Related Subject Headings
- Surgery
- Phospholipids
- Infusions, Parenteral
- Glucagon
- Female
- Dogs
- Disease Models, Animal
- Chronic Disease
- Cholesterol
- Cholestasis