Inhibition of bile flow by intravenous arginine hydrochloride.

Journal Article (Journal Article)

One proposed mechanism for the cholestasis associated with total parenteral nutrition is infusion of amino acids. Arginine, 19 mumol/kg/min, was infused for a short time in healthy dogs with a biliary fistula to test the effect of endogenous hormone release on bile flow and composition. Both plasma glucagon and blood glucose levels increased. Despite the release of the choleretic hormone, glucagon, bile flow decreased 30%. The suppression of bile flow was attributed to a decrease in the bile acid-dependent fraction of bile flow. Bile acid, cholesterol, and phospholipid output were all depressed.

Full Text

Duke Authors

Cited Authors

  • Rotolo, FS; Meyers, WC

Published Date

  • September 1985

Published In

Volume / Issue

  • 98 / 3

Start / End Page

  • 459 - 464

PubMed ID

  • 4035568

International Standard Serial Number (ISSN)

  • 0039-6060


  • eng

Conference Location

  • United States