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Inhibition of bile flow by intravenous arginine hydrochloride.

Publication ,  Journal Article
Rotolo, FS; Meyers, WC
Published in: Surgery
September 1985

One proposed mechanism for the cholestasis associated with total parenteral nutrition is infusion of amino acids. Arginine, 19 mumol/kg/min, was infused for a short time in healthy dogs with a biliary fistula to test the effect of endogenous hormone release on bile flow and composition. Both plasma glucagon and blood glucose levels increased. Despite the release of the choleretic hormone, glucagon, bile flow decreased 30%. The suppression of bile flow was attributed to a decrease in the bile acid-dependent fraction of bile flow. Bile acid, cholesterol, and phospholipid output were all depressed.

Duke Scholars

Published In

Surgery

ISSN

0039-6060

Publication Date

September 1985

Volume

98

Issue

3

Start / End Page

459 / 464

Location

United States

Related Subject Headings

  • Surgery
  • Phospholipids
  • Infusions, Parenteral
  • Glucagon
  • Female
  • Dogs
  • Disease Models, Animal
  • Chronic Disease
  • Cholesterol
  • Cholestasis
 

Citation

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Rotolo, F. S., & Meyers, W. C. (1985). Inhibition of bile flow by intravenous arginine hydrochloride. Surgery, 98(3), 459–464.
Rotolo, F. S., and W. C. Meyers. “Inhibition of bile flow by intravenous arginine hydrochloride.Surgery 98, no. 3 (September 1985): 459–64.
Rotolo FS, Meyers WC. Inhibition of bile flow by intravenous arginine hydrochloride. Surgery. 1985 Sep;98(3):459–64.
Rotolo, F. S., and W. C. Meyers. “Inhibition of bile flow by intravenous arginine hydrochloride.Surgery, vol. 98, no. 3, Sept. 1985, pp. 459–64.
Rotolo FS, Meyers WC. Inhibition of bile flow by intravenous arginine hydrochloride. Surgery. 1985 Sep;98(3):459–464.
Journal cover image

Published In

Surgery

ISSN

0039-6060

Publication Date

September 1985

Volume

98

Issue

3

Start / End Page

459 / 464

Location

United States

Related Subject Headings

  • Surgery
  • Phospholipids
  • Infusions, Parenteral
  • Glucagon
  • Female
  • Dogs
  • Disease Models, Animal
  • Chronic Disease
  • Cholesterol
  • Cholestasis