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The approach to the patient with single and multiple liver metastases, pulmonary metastases, and intra-abdominal metastases from colorectal carcinoma.

Publication ,  Journal Article
VanderMeer, TJ; Callery, MP; Meyers, WC
Published in: Hematol Oncol Clin North Am
August 1997

Recurrent colorectal carcinoma constitutes a major health care problem, with 90,000 patients diagnosed annually with metastatic disease. Recent advances have offered treatment to selected patients with liver, lung, and intra-abdominal metastases. Resection of liver secondary tumors improves 5-year survival from 0% to approximately 30% and offers the only possibility for cure. As experience mounts, hepatic surgery can be performed with quite acceptable morbidity and mortality. Adjuvant therapies are being developed that may improve results with surgery alone. Cryoablation is a new technique that appears to effectively eradicate liver tumors, but its role remains to be defined. In patients with unresectable disease, the benefit of hepatic artery infusion of chemotherapy is unproven. Resection of pulmonary metastases significantly improves survival in patients with solitary nodules. Consistent data regarding the benefit of pulmonary metastatectomy in patients with multiple nodules are not available. Combined cytoreductive surgery and intraperitoneal hyperthermic chemotherapy is being investigated as a treatment for peritoneal carcinomatosis from colorectal cancer. Although selected patients may benefit, this combined treatment modality appears to be less effective in patients with colorectal cancer than with other types of cancer.

Duke Scholars

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

August 1997

Volume

11

Issue

4

Start / End Page

759 / 777

Location

United States

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Combined Modality Therapy
  • Colorectal Neoplasms
  • Abdominal Neoplasms
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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VanderMeer, T. J., Callery, M. P., & Meyers, W. C. (1997). The approach to the patient with single and multiple liver metastases, pulmonary metastases, and intra-abdominal metastases from colorectal carcinoma. Hematol Oncol Clin North Am, 11(4), 759–777. https://doi.org/10.1016/s0889-8588(05)70459-7
VanderMeer, T. J., M. P. Callery, and W. C. Meyers. “The approach to the patient with single and multiple liver metastases, pulmonary metastases, and intra-abdominal metastases from colorectal carcinoma.Hematol Oncol Clin North Am 11, no. 4 (August 1997): 759–77. https://doi.org/10.1016/s0889-8588(05)70459-7.
VanderMeer, T. J., et al. “The approach to the patient with single and multiple liver metastases, pulmonary metastases, and intra-abdominal metastases from colorectal carcinoma.Hematol Oncol Clin North Am, vol. 11, no. 4, Aug. 1997, pp. 759–77. Pubmed, doi:10.1016/s0889-8588(05)70459-7.
Journal cover image

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

August 1997

Volume

11

Issue

4

Start / End Page

759 / 777

Location

United States

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Combined Modality Therapy
  • Colorectal Neoplasms
  • Abdominal Neoplasms
  • 1102 Cardiorespiratory Medicine and Haematology