The Role of Serotonin in Posttraumatic Stress Disorder: Neurobiology and Pharmacotherapy

Journal Article (Journal Article)

Much attention has been given to the role of catecholamine dysfunction in posttraumatic stress disorder (PTSD), and only recently have researchers begun to focus on serotonin (5-HT) in PTSD. Serotonin appears to be a factor in responses followin extreme stress, such as those that precede PTSD. In this review, the authors provide a brief overview of the concept of PTSD and specific issues of clinical concern. The role 5-HT in the neurobiology of PTSD is explored in a review of animal model studies and of clinical investigations of paroxetine binding, pharmacologic challenges, and neuroimaging. Data on the use of 5-HT in PTSD treatment are provided in a review of both open-label and controlled studies of serotonergically active drugs. © 1998, Cambridge University Press. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Connor, KM; Davidson, JRT

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 3 / S2

Start / End Page

  • 42 - 51

Electronic International Standard Serial Number (EISSN)

  • 2165-6509

International Standard Serial Number (ISSN)

  • 1092-8529

Digital Object Identifier (DOI)

  • 10.1017/S1092852900007318

Citation Source

  • Scopus