The Role of Serotonin in Posttraumatic Stress Disorder: Neurobiology and Pharmacotherapy
Journal Article (Journal Article)
Much attention has been given to the role of catecholamine dysfunction in posttraumatic stress disorder (PTSD), and only recently have researchers begun to focus on serotonin (5-HT) in PTSD. Serotonin appears to be a factor in responses followin extreme stress, such as those that precede PTSD. In this review, the authors provide a brief overview of the concept of PTSD and specific issues of clinical concern. The role 5-HT in the neurobiology of PTSD is explored in a review of animal model studies and of clinical investigations of paroxetine binding, pharmacologic challenges, and neuroimaging. Data on the use of 5-HT in PTSD treatment are provided in a review of both open-label and controlled studies of serotonergically active drugs. © 1998, Cambridge University Press. All rights reserved.
Full Text
Duke Authors
Cited Authors
- Connor, KM; Davidson, JRT
Published Date
- January 1, 1998
Published In
Volume / Issue
- 3 / S2
Start / End Page
- 42 - 51
Electronic International Standard Serial Number (EISSN)
- 2165-6509
International Standard Serial Number (ISSN)
- 1092-8529
Digital Object Identifier (DOI)
- 10.1017/S1092852900007318
Citation Source
- Scopus