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Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo.

Publication ,  Journal Article
Davidson, J; Stein, DJ; Rothbaum, BO; Pedersen, R; Szumski, A; Baldwin, DS
Published in: J Psychopharmacol
June 2012

This post-hoc analysis evaluated resilience as a predictor of treatment response in patients with posttraumatic stress disorder (PTSD). Data were pooled from two randomized, double-blind studies conducted with adult outpatients treated with flexible doses of venlafaxine extended release (ER) 37.5 to 300 mg/day or placebo. The 17-item Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS-SX(17)) was the primary outcome measure. Baseline Connor-Davidson Resilience Scale (CD-RISC) scores for the 25-, 10-, and 2-item versions were used to predict changes in PTSD symptom severity at week 12 and symptomatic remission (CAPS-SX(17) ≤ 20). Analyses were conducted for the overall population and separately for the individual treatment groups. In total, pretreatment resilience predicted a positive treatment response. For the overall population, all versions of the CD-RISC predicted CAPS-SX(17) change scores and remission after controlling for variables such as treatment group and baseline symptom severity. For venlafaxine ER-treated patients, all versions of the CD-RISC were predictive of remission, but only the 10-item version was predictive of CAPS-SX(17) change score. Our results suggest that higher pretreatment resilience is generally associated with a positive treatment response. Future research may be warranted to explore the relationship between response to active treatment and the spectrum of resiliency.

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Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

June 2012

Volume

26

Issue

6

Start / End Page

778 / 783

Location

United States

Related Subject Headings

  • Venlafaxine Hydrochloride
  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Resilience, Psychological
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Humans
  • Female
  • Double-Blind Method
 

Citation

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Davidson, J., Stein, D. J., Rothbaum, B. O., Pedersen, R., Szumski, A., & Baldwin, D. S. (2012). Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo. J Psychopharmacol, 26(6), 778–783. https://doi.org/10.1177/0269881111413821
Davidson, Jonathan, Dan J. Stein, Barbara O. Rothbaum, Ron Pedersen, Annette Szumski, and David S. Baldwin. “Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo.J Psychopharmacol 26, no. 6 (June 2012): 778–83. https://doi.org/10.1177/0269881111413821.
Davidson J, Stein DJ, Rothbaum BO, Pedersen R, Szumski A, Baldwin DS. Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo. J Psychopharmacol. 2012 Jun;26(6):778–83.
Davidson, Jonathan, et al. “Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo.J Psychopharmacol, vol. 26, no. 6, June 2012, pp. 778–83. Pubmed, doi:10.1177/0269881111413821.
Davidson J, Stein DJ, Rothbaum BO, Pedersen R, Szumski A, Baldwin DS. Resilience as a predictor of treatment response in patients with posttraumatic stress disorder treated with venlafaxine extended release or placebo. J Psychopharmacol. 2012 Jun;26(6):778–783.
Journal cover image

Published In

J Psychopharmacol

DOI

EISSN

1461-7285

Publication Date

June 2012

Volume

26

Issue

6

Start / End Page

778 / 783

Location

United States

Related Subject Headings

  • Venlafaxine Hydrochloride
  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Resilience, Psychological
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Humans
  • Female
  • Double-Blind Method