A double-blind comparison of bupropion and amitriptyline in depressed inpatients.

Journal Article (Clinical Trial;Journal Article)

Bupropion and amitriptyline were compared in a double-blind study of depressed inpatients. Treatment ranged from 2 to 4 weeks: early responders (Hamilton Depression Scale scores less than 10) were often removed from treatment after 2 or 3 weeks. Twenty-two patients completed treatment with bupropion and 18 with amitriptyline. Doses ranged from 450 to 750 mg/day for bupropion and 75 to 225 mg/day for amitriptyline. Overall, bupropion and amitriptyline were equally effective, as measured by the Hamilton Depression and Anxiety scales, Clinical Global Impressions, Zung Depression scale, and the SCL-90. Differences in the side effect profile and in weight change are described.

Full Text

Duke Authors

Cited Authors

  • Davidson, J; Miller, R; Van Wyck Fleet, J; Strickland, R; Manberg, P; Allen, S; Parrott, R

Published Date

  • May 1983

Published In

Volume / Issue

  • 44 / 5 Pt 2

Start / End Page

  • 115 - 117

PubMed ID

  • 6406438

International Standard Serial Number (ISSN)

  • 0160-6689


  • eng

Conference Location

  • United States