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A double-blind comparison of bupropion and amitriptyline in depressed inpatients.

Publication ,  Journal Article
Davidson, J; Miller, R; Van Wyck Fleet, J; Strickland, R; Manberg, P; Allen, S; Parrott, R
Published in: J Clin Psychiatry
May 1983

Bupropion and amitriptyline were compared in a double-blind study of depressed inpatients. Treatment ranged from 2 to 4 weeks: early responders (Hamilton Depression Scale scores less than 10) were often removed from treatment after 2 or 3 weeks. Twenty-two patients completed treatment with bupropion and 18 with amitriptyline. Doses ranged from 450 to 750 mg/day for bupropion and 75 to 225 mg/day for amitriptyline. Overall, bupropion and amitriptyline were equally effective, as measured by the Hamilton Depression and Anxiety scales, Clinical Global Impressions, Zung Depression scale, and the SCL-90. Differences in the side effect profile and in weight change are described.

Duke Scholars

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

May 1983

Volume

44

Issue

5 Pt 2

Start / End Page

115 / 117

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Propiophenones
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Female
  • Double-Blind Method
  • Depressive Disorder
 

Citation

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Davidson, J., Miller, R., Van Wyck Fleet, J., Strickland, R., Manberg, P., Allen, S., & Parrott, R. (1983). A double-blind comparison of bupropion and amitriptyline in depressed inpatients. J Clin Psychiatry, 44(5 Pt 2), 115–117.
Davidson, J., R. Miller, J. Van Wyck Fleet, R. Strickland, P. Manberg, S. Allen, and R. Parrott. “A double-blind comparison of bupropion and amitriptyline in depressed inpatients.J Clin Psychiatry 44, no. 5 Pt 2 (May 1983): 115–17.
Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, et al. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. J Clin Psychiatry. 1983 May;44(5 Pt 2):115–7.
Davidson, J., et al. “A double-blind comparison of bupropion and amitriptyline in depressed inpatients.J Clin Psychiatry, vol. 44, no. 5 Pt 2, May 1983, pp. 115–17.
Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. J Clin Psychiatry. 1983 May;44(5 Pt 2):115–117.

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

May 1983

Volume

44

Issue

5 Pt 2

Start / End Page

115 / 117

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Propiophenones
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Female
  • Double-Blind Method
  • Depressive Disorder