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Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison.

Publication ,  Journal Article
Koran, LM; McElroy, SL; Davidson, JR; Rasmussen, SA; Hollander, E; Jenike, MA
Published in: J Clin Psychopharmacol
April 1996

The efficacy and tolerability of fluvoxamine (100-300 mg/day) and clomipramine (100-250 mg/day) were compared in a randomized, double-blind, parallel-group study of 79 patients with obsessive-compulsive disorder (OCD) without coexisting major depression. After a 2-week placebo lead-in period, patients were randomized to fluvoxamine (37 patients) or clomipramine (42 patients) for 10 weeks. Efficacy was evaluated with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the National Institute of Mental Health Obsessive-Compulsive scale, and Patient and Clinical Global Improvement scales. Hamilton Rating Scale for Depression scores and somatic symptoms were also assessed. Seventy-eight percent of fluvoxamine patients and 64% of clomipramine patients completed the study. At the end of treatment, 56% of fluvoxamine patients were classified as responders (> or = 25% decrease in Y-BOCS score), compared with 54% of clomipramine patients. Both groups showed steady improvement throughout the study; no statistically significant differences were observed between the groups for any efficacy variable at any time. A similar percentage of patients in both groups withdrew because of adverse events. No serious adverse events related to drug occurred with either drug. Insomnia, nervousness, and dyspepsia were more statistically frequent with fluvoxamine; dry mouth and postural hypotension were more frequent with clomipramine. In this study, fluvoxamine and clomipramine were equally effective in reducing OCD symptoms over a 10-week treatment period but displayed different side effect profiles.

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Published In

J Clin Psychopharmacol

DOI

ISSN

0271-0749

Publication Date

April 1996

Volume

16

Issue

2

Start / End Page

121 / 129

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Personality Inventory
  • Obsessive-Compulsive Disorder
  • Middle Aged
  • Male
  • Humans
  • Fluvoxamine
  • Female
 

Citation

APA
Chicago
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Koran, L. M., McElroy, S. L., Davidson, J. R., Rasmussen, S. A., Hollander, E., & Jenike, M. A. (1996). Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. J Clin Psychopharmacol, 16(2), 121–129. https://doi.org/10.1097/00004714-199604000-00004
Koran, L. M., S. L. McElroy, J. R. Davidson, S. A. Rasmussen, E. Hollander, and M. A. Jenike. “Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison.J Clin Psychopharmacol 16, no. 2 (April 1996): 121–29. https://doi.org/10.1097/00004714-199604000-00004.
Koran LM, McElroy SL, Davidson JR, Rasmussen SA, Hollander E, Jenike MA. Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. J Clin Psychopharmacol. 1996 Apr;16(2):121–9.
Koran, L. M., et al. “Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison.J Clin Psychopharmacol, vol. 16, no. 2, Apr. 1996, pp. 121–29. Pubmed, doi:10.1097/00004714-199604000-00004.
Koran LM, McElroy SL, Davidson JR, Rasmussen SA, Hollander E, Jenike MA. Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. J Clin Psychopharmacol. 1996 Apr;16(2):121–129.

Published In

J Clin Psychopharmacol

DOI

ISSN

0271-0749

Publication Date

April 1996

Volume

16

Issue

2

Start / End Page

121 / 129

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Personality Inventory
  • Obsessive-Compulsive Disorder
  • Middle Aged
  • Male
  • Humans
  • Fluvoxamine
  • Female