A comparison of phenelzine and imipramine in depressed inpatients.

Journal Article (Clinical Trial;Journal Article)

Phenelzine and imipramine were compared double-blind, in 43 depressed inpatients. A placebo week preceded drug treatment; this allowed early identification of placebo responders who did not therefore enter the study. After three weeks treatment, the two drugs were equally effective on Hamilton, Beck and SCL-90 measures of depression and anxiety. On the the SCL-90 scales of hostility and paranoia imipramine was more effective; in some patients phenelzine was associated with increased hostility. Measurement of MAO inhibition and plasma tricyclic levels indicated that adequate doses were generally used - (mean 81 mg/day phenelzine and 144 mg/day imipramine).

Full Text

Duke Authors

Cited Authors

  • Davidson, JR; McLeod, MN; Turnbull, CD; Miller, RD

Published Date

  • October 1, 1981

Published In

Volume / Issue

  • 42 / 10

Start / End Page

  • 395 - 397

PubMed ID

  • 7026542

International Standard Serial Number (ISSN)

  • 0160-6689


  • eng

Conference Location

  • United States