The importance of dose in isocarboxazid therapy.

Journal Article

Little information is available on the effectiveness and safety of particular doses of isocarboxazid. In a study using isocarboxazid doses of 30 and 50 mg/day in depressed inpatients, the higher dose was well tolerated and did not result in any greater toxicity than the 30 mg dose. Significantly greater elevation of plasma serotonin (Week 2) and platelet MAO inhibition were seen with 50 mg/day. In nonmelancholic depressions, 50 mg proved to be more effective than 30 mg in symptoms of depression and anxiety. However, this did not apply to the vegetative-physiologic symptoms of depression.

Duke Authors

Cited Authors

  • Davidson, J; Turnbull, C

Published Date

  • July 1, 1984

Published In

Volume / Issue

  • 45 / 7 Pt 2

Start / End Page

  • 49 - 52

PubMed ID

  • 6735995

Electronic International Standard Serial Number (EISSN)

  • 1555-2101

International Standard Serial Number (ISSN)

  • 0160-6689

Language

  • eng